Margaret S. Ho 何淑君 - 國立陽明交通大學神經科學研究所

Margaret S. Ho Associate Professor

E-mail: margaret.ho@nycu.edu.tw
TEL（office）:+886-2-2826-7998
TEL（Lab）: +886-2-2826-6099
FAX: +886-2-2820-0259
Laboratory of NeuroGlia: https://cerise-wombat-l2qvgf.mystrikingly.com/
CV
CV

EXPERIENCE PUBLICATIONS LABORATORY

Educations

2003, Ph.D., Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, USA

1999, B.A., Molecular Biology and Biochemistry, University of California at Berkeley, Berkeley, California, USA

Positions

2024, Associate Professor, Institute of Neuroscience, National Yang Ming Chiao Tung University, Taipei, Taiwan

2017-2023, Associate Professor, School of Life Sciences and Technology, ShanghaiTech University, Shanghai, China (Tenured since 2022)

2010-2017, Professor/Distinguished Research Fellow, School of Medicine, Tongji University, Shanghai, China

2003-2010, Postdoctoral Fellow, Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan

1999, Research Assistant, Dr. Gregory Verdine’s laboratory, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, USA

Honors

2030 Cross-generation International Outstanding Young Scholar, NSTC

Representative Papers

Original Research Articles
1. Wang L, Yi S, Zhang S, Tsai Y, Wang H, Ho MS^#, 2024, New Atg9 phosphorylation sites regulate autophagic trafficking in glia, bioRxiv, July 3, 2024.07.03.601894
2. Zhang S, Wang L, Yi S, Li S, Wang H, Wang R, Liu Y, Yan W, Liu C, He K, Ho MS^#, 2023, A phosphorylation-dependent switch of the lysosomal V-ATPase assembly regulates α-synuclein clearance in glia, bioRxiv, Dec 8, 2023.12.07.570521
3. Wang L, Zhang S, Yi S, Ho MS^#, 2023, A new regulator of autophagy initiation in glia, Autophagy, Aug 29;1-3, invited commentary.
4. Wang M and Ho MS^#, 2023, Profiling neurotransmitter-evoked glial responses by RNA-sequencing analysis, Neural Circuits 17:1252759.
5. Zhang S, Yi S, Wang L, Li S, Wang H, Song L, Ou J, Zhang M, Wang M, Zheng Y, Wang R, Yang K, Liu T, Ho MS^#, 2023, Cyclin-G-associated kinase GAK/dAux regulates autophagy initiation via ULK1/Atg1 in glia, Proc Natl Acad Sci U S A, Jul 18;120(29):e2301002120 (featured in Logical Thinking Neuroscience and BioArtMED Wechat public forums).
6. Li T, Shi W, Ho MS^#, Zhang YQ^#, 2023, A Pvr–AP-1–Mmp1 signaling pathway is activated in astrocytes upon traumatic brain injury, eLife, 12:RP87258 (featured in Brainnews Wechat public forum).
7. Wang L, Wang H, Yi S, Zhang S, Ho MS^#, 2022, A LRRK2/dLRRK-mediated lysosomal pathway that contributes to glial cell death and DA neuron survival, Traffic, Oct;23(10):506-520 (featured on the Cover).
8. Yang M, Wang H, Chen C, Zhang S, Wang M, Senapati B, Li S, Yi S, Wang L, Zhang M, Yin S, He Y, Xue L, Lin S, Ho MS^#, 2021, Glia-derived temporal signals orchestrate neurogenesis in the Drosophila mushroom body, Proc Natl Acad Sci U S A, 118(23):e2020098118 (featured in Logical Thinking Neuroscience Wechat public forum).
9. Liu YJ^#, Zhang T, Chen S, Cheng D, Wu C, Wang X, Duan D, Zhu L, Lou H, Gong Z, Wang XD^#, Ho MS^#, Duan S, 2021, The noncanonical role of the protease cathepsin D as a cofilin phosphatase, Cell Res, 31(7):801-813 (last corresponding author).
10. Liu YJ, Zhang T, Cheng D, Yang J, Chen S, Wang X, Li X, Duan D, Lou H, Zhu L, Luo J, Ho MS^#, Wang XD^#, Duan S^#, 2020, Late endosomes promote microglia migration via cytosolic translocation of immature protease cathD, Sci Adv, 6(50):eaba5783.
11. Cao W, Song L, Cheng J, Yi N, Cai L, Huang FD, Ho MS^#, 2017, An automated rapid iterative negative geotaxis assay for analyzing adult climbing behavior in a Drosophila model of neurodegeneration, J Vis Exp, (127):56507.
12. Xiao X, Chen C, Yu TM, Ou J, Rui M, Zhai Y, He Y, Xue L, Ho MS^#, 2017, Molecular chaperone Calnexin regulates the function of Drosophila sodium channel Paralytic, Front Mol Neurosci, 10:57.
13. Song L, He Y, Ou J, Zhao Y, Li R, Cheng J, Lin CH, Ho MS^#, 2017, Auxilin underlies progressive locomotor deficits and dopaminergic neuron loss in a Drosophila model of Parkinson’s disease, Cell Rep, 18(5):1132-1143.

EditorialsReviews, Chapters, and Books

Ho MS^#, Verkhratsky A^#, Duan S^#, Parpura V^#, 2019, Editorial: Glia in health and disease, Front Mol Neurosci, 12:63.
Ho MS^#, 2014, Neurodevelopment and degeneration, Neurosci Bull, 30(4):539-41.
Ho MS^#, 2017, Neuroglial crosstalk by mitochondria, Neurosci Bull, 33(1):111-112.
Ho MS^#, 2019, Microglia in Parkinson’s disease-Neuroglia in neurodegenerative diseases, Adv Exp Med Biol, 1175:335-353.
Wang L, Wang H, Ho MS^#, 2019, Drosophila glia, Colloquium series on neuroglia in biology and medicine: from physiology to disease, Morgan & Claypool Publishers.
Ho MS^# and Duan, S^#, 2013, Purinergic mechanisms in glial cells, invited book chapter, Neuroglia, Oxford University Press, 306-319.
Yi S, Wang L, Wang H, Ho MS^#, Zhang S^#, 2022, Pathogenesis of α-synuclein in Parkinson’s Disease: From a Neuron-Glia Crosstalk Perspective, J. Mol. Sci. 23, 14753 (IJMS Top View papers in 2022).
Cheng J, Lu Q, Song L, Ho MS^#, 2018, α-Synuclein Trafficking in Parkinson’s Disease: Insights From Fly and Mouse Models, ASN Neuro, 10:1759091418812587.

Research Interest

Neuroglia

Neurodegenerative Diseases

Behavioral and Emotional Circuits

Our overall research objective is to understand the function of the brain cells “glia” under normal and pathological conditions. As the most abundant cell types in the nervous system, glia participate in virtually all aspects of brain function. Dysfunction in glial cells causes serious and significant pathology that leads to multiple brain diseases. The laboratory has made unique contribution to this field, including: 1)

elucidated the mechanism of ubiquitination proteasome system (UPS) in regulating

gliogenesis (PNAS 2009, Sci Rep 2017), neural stem cell differentiation (PNAS 2021), and synaptic pruning/neuronal remodeling (JGG 2017, Front Mol Neurosci 2021); 2) established an in-vivo fly Parkinson’s disease (PD) model for rapid screening of novel pathological regulators and new PD risk factors (Cell Rep 2017 and JOVE 2017); 3) identified a new factor in glial autophagy (PNAS 2023 and Autophagy 2023); 4) unraveled the mechanism of lysosome-related function under pathological conditions (Sci Adv 2020, Cell Res 2021, Traffic 2022, bioRxiv 2021). These achievements are summarized below.

Summary of research achievements by the Ho laboratory.

The current research directions include:

Glia-mediated mechanisms in PD: how glial proteostasis and inflammation contributes to both motor and non-motor behaviors in PD.
Neurochemical basis of gliotransmission in behavior: explore the neurochemical mechanism of neuron-glia interaction, and investigate how they contribute to both learning and innate behaviors.

Future directions on Glia.