Cheng-Chang Lien 連正章 - 國立陽明交通大學神經科學研究所

Cheng-Chang Lien Chair Professor, INS/ Dean, College of Life Sciences

- E-mail : cclien@nycu.edu.tw
- Office phone: +886-2-2826-7325
  Lab phone: +886-2-2826-7000 ext. 66090
- FAX : +886-2-2821-5307
- Website: Laboratory of Molecular and Cellular Neurophysiology
- CV: Cheng-Chang Lien

EXPERIENCE PUBLICATIONS LABORATORY INFO LAB MEMBERS OTHER INFO

Educations

PhD from Albert-Ludwigs-Universitat Freiburg, Germany – 1998~2003

Medical doctor (MD) from China Medical University, Taiwan – 1990~1997

Positions

Since 2025.01：Contract research fellow , Taipei Veterans General Hospital

Since 2023.01：Convener of the Morphological Medicine and Physiology Division, National Science and Technology Council, Taiwan

Since 2023.08：Permanent Distinguished Professor at NYCU, Institute of Neuroscience, Taiwan

Since 2023.11：Director of Life Sciences Research Promotion Center (LSRPC), National Science and Technology Council, Taiwan

Since 2021.02：Professor at NYCU, Institute of Neuroscience, Taiwan

Since 2020.11：Dean of School of Life Sciences, National Yang Ming Chiao Tung University, Taiwan

2017.08~2023.07：Distinguished Professor at NYCU, Institute of Neuroscience, Taiwan

2017.01~2021.08：Director of the Institute of Neuroscience, National Yang Ming Chiao Tung University, Taiwan

2015~2019：Visiting Professor at Charite – Medical University of Berlin, Germany

2015.08~2021.01：Professor at NYMU, Institute of Neuroscience, Taiwan

2011.02~2015.07：Associate Professor at NYMU, Institute of Neuroscience, Taiwan

2006.07~2011.01：Assistant Professor at NYMU, Institute of Neuroscience, Taiwan

2004.01~2006.07：Postdoc. at University of California Berkeley, Department of Molecular and Cell Biology, USA

2003.04~2004.02：Postdoc. at Albert-Ludwigs-Universitat Freiburg, Germany

1997.07~1998.06：Resident at Department of Neurology, National Taiwan University Hospital

Honors

2024：National Science and Technology Council (NSTC) Outstanding Research Award

2024：”Integrated Biomedical and Health Technology Research Program” for 6 times

2020.02：Honors with Qualifications for Permanent Assessment Exemption for Teachers

2011~2019：NYMU Academic Excellence Award

2016：Ministry of Science and Technology (MOST) Outstanding Research Award

2016.04：German Humboldt Fellowship for Experienced Researchers

2016：”Newly Approved Integrated Research Grants in Health and Medical Sciences” for 3 times

2015.12：Young Scientist Award – TienTe Lee Biomedical Foundation

2015.10：NeuroCure Fellow of Charité – Universitätsmedizin Berlin

2012：DAAD Scholarship for the research visit at the Institute for Physiology and Pathophysiology, Ruprecht-Karls-Universität Heidelberg, Germany

1998~2003：German Academic Exchange Service (DAAD) scholarship for PhD study

2008~2022：Outstanding Educator Award from School of Medicine, NYMU & NYCU. (2022/05, 2021/05, 2020/07, 2018/04,2017/10,2016/05, 2015/05, 2013/05, 2012/05, 2010/11,2010/03, 2008/10)

Peer-Reviewed Papers

1. Li YJ, Yeh CW, Abdulmajeed WI, Ajibola MI, Lien CC.Morpho-physiological Diversity of Cholecystokinin-expressing Interneurons in the Dentate Gyrus. J Physiol Investig. 2024 Sep 1;67(5):258-269. doi: 10.4103/ejpi.EJPI-D-24-00065. Epub 2024 Oct 28. [PDF] [Link] [PubMed]
2. Wu PY, Lien CC. Modulation of Neurotransmission by Acid-Sensing Ion Channels. J Physiol Investig. 2024 Sep 1;67(5):242-248. doi: 10.4103/ejpi.EJPI-D-24-00062. Epub 2024 Sep 17. [PDF] [Link] [PubMed]
3. Hou WH, Jariwala M, Wang KY, Seewald A, Lin YL, Liou YC, Ricci A, Ferraguti F, Lien CC, Capogna M. Inhibitory fear memory engram in the mouse central lateral amygdala. Cell Reports. 2024 Aug 27;43(8):114468. doi: 10.1016/j.celrep.2024.114468. Epub 2024 Aug 5. (corresponding author and lead contact) [PDF] [PubMed] [季重要期刊論文_1] [季重要期刊論文_2] [JCR] [WOS]
4. Ramos-Prats A, Matulewicz P, Edenhofer ML, Wang KY, Yeh CW, Fajardo-Serrano A, Kress M, Kummer K, Lien CC, Ferraguti F. Loss of mGlu5 receptors in somatostatin-expressing neurons alters negative emotional states. Mol Psychiatry. 2024 Sep;29(9):2774-2786. doi: 10.1038/s41380-024-02541-5. Epub 2024 Apr 4. [PDF] [PubMed] [季重要期刊論文_1] [季重要期刊論文_2] [JCR] [WOS]
5. Huang DF, Lin CW, Yang TY, Lien CC, Yang CH, Huang HS. An intersectional genetic approach for simultaneous cell type-specific labelling and gene knockout in the mouse. Development. 2023 Feb 15;150(4):dev201198. doi: 10.1242/dev.201198. [PDF] [PubMed] [JCR] [WOS]
6. Huang TH, Lin YS, Hsiao CW, Wang LY, Ajibola MI, Abdulmajeed WI, Lin YL, Li YJ, Chen CY, Lien CC, Chiu CD, Cheng IH. Differential expression of GABAA receptor subunits δ and α6 mediates tonic inhibition in parvalbumin and somatostatin interneurons in the mouse hippocampus. Frontiers in Cellular Neuroscience. 2023 Jul 20;17:1146278. doi: 10.3389/fncel.2023.1146278. [PDF] [PubMed] [JCR] [WOS]
7. Jin X, Xie J, Yeh CW, Chen JC, Cheng CJ, Lien CC, Huang CL. WNK1 promotes water homeostasis by acting as a central osmolality sensor for arginine vasopressin release. J Clin Invest. 2023 Jun 1;133(11):e164222. doi: 10.1172/JCI164222.(co-corresponding author) [PDF] [PubMed] [季重要期刊論文] [重要論文推薦表] [JCR] [WOS]
8. Chou TM, Lee ZF, Wang SJ, Lien CC, Chen SP. CGRP-dependent sensitization of PKC-δ positive neurons in central amygdala mediates chronic migraine. J. Headache & Pain. 2022 Dec 12;23(1):157. doi: 10.1186/s10194-022-01531-8. (co-corresponding author) [PDF] [PubMed] [IG news] [FB news] [季重要期刊論文] [重要論文推薦表] [JCR] [WOS]
9. Lin YL, Yang ZS, Wong WY, Lin SC, Wang SJ, Chen SP, Cheng JK, Lu H, Lien CC. Cellular mechanisms underlying central sensitization in a mouse model of chronic muscle pain. eLife. 2022 Nov 15;11:e78610. doi: 10.7554/eLife.78610. [PDF] [PubMed] [FB news] [JCR] [WOS]
10. Huang PH, Yang TY, Yeh CW, Huang SM, Chang HC, Hung YF, Chu WC, Cho KH, Lu TP, Kuo PH, Lee LJ, Kuo LW, Lien CC, Cheng HJ. Involvement of a BH3-only apoptosis sensitizer gene Blm-s in hippocampus-mediated mood control.Transl. Psychiatry. 2022 Sep 26;12(1):411. doi: 10.1038/s41398-022-02184-6. [PDF] [PubMed] [JCR] [WOS]
11. Devina T, Wong YH, Hsiao CW, Li YJ, Lien CC, Cheng IH. Endoplasmic reticulum stress induces Alzheimer disease-like phenotypes in the neuron derived from the induced pluripotent stem cell with D678H mutation on amyloid precursor protein. J Neurochem. 2022 Aug 9. doi: 10.1111/jnc.15687. Online ahead of print. [PDF] [PubMed] [cover] [JCR] [WOS]
12. Huang DF, Lee CY, Chou MY, Yang TY, Cao X, Hsiao YH, Wu RN, Lien CC, Huang YS, Huang HP, Gau SF, Huang HS. Neuronal splicing regulator RBFOX3 mediates seizures via regulating Vamp1 expression preferentially in NPY-expressing GABAergic neurons. Proc Natl Acad Sci USA. 2022 Aug 16;119(33):e2203632119. doi: 10.1073/pnas.2203632119. [PDF] [PubMed] [JCR] [WOS]
13. Abdulmajeed W, Wang KY, Wu JW, Ajibola MI, Cheng IH, Lien CC. Connectivity and synaptic features of hilar mossy cells and their effects on granule cell activity along the hippocampal longitudinal axis. J Physiol. 2022 Jul;600(14):3355-3381. doi: 10.1113/JP282804. [PDF] [PubMed] [cover1] [cover2] [This article relates to] [JCR] [WOS]
14. Yen TY, Huang X, MacLaren DAA, Schlesiger MI, Monyer H, Lien CC. Inhibitory projections connecting the dentate gyri in the two hemispheres support spatial and contextual memory. Cell Rep. 2022 May 17;39(7):110831. doi: 10.1016/j.celrep.2022.110831. [PDF] [PubMed] [Chinese Graphical Summary] [JCR] [WOS]
15. Chen WH, Lien CC, Chen CC. Neuronal basis for pain-like and anxiety-like behaviors in the central nucleus of the amygdala. Pain. 2022 Mar 1;163(3):e463-e475. doi: 10.1097/j.pain.0000000000002389. [PDF] [PubMed] [JCR] [WOS]
16. Feng KL, Weng JY, Chen CC, Abubaker MB, Lin HW, Charng CC, Belle JS, Tully T, Lien CC, Chiang AS. Neuropeptide F inhibits dopamine neuron interference of long-term memory consolidation in Drosophila. iScience. 2021 Nov 25;24(12):103506. doi: 10.1016/j.isci.2021.103506. (co-corresponding author)[PDF] [PubMed] [JCR] [WOS]
17. Ajibola MI, Wu JW, Abdulmajeed W, Lien CC. Hypothalamic glutamate/GABA co-transmission modulates hippocampal circuits and supports long-term potentiation. J. Neurosci. 2021 Sep 29;41(39):8181-8196. doi: 10.1523/JNEUROSCI.0410-21.2021. [PDF] [PubMed] [JCR] [WOS]
18. Wang KY, Wu JW, Cheng JK, Chen CC, Wong WY, Averkin RG, Tamás G, Nakazawa K, Lien CC. Elevation of hilar mossy cell activity suppresses hippocampal excitability and avoidance behavior. Cell Rep. 2021 Sep 14;36(11):109702. doi: 10.1016/j.celrep.2021.109702. [PDF] [PubMed] [cover] [MOST GASE] [JCR] [WOS]
19. Wei YT, Wu JW, Yeh CW, Shen HC, Wu KP, Vida I., Lien CC. Morpho-physiological properties and connectivity of vasoactive intestinal polypeptide-expressing interneurons in the mouse hippocampal dentate gyrus. J. Comp. Neurol. 2021 Jul 1;529(10):2658-2675. doi: 10.1002/cne.25116. [PDF] [PubMed] [JCR] [WOS]
20. Wu PC, Fann MJ, Tran TT, Chen SC, Devina T, Cheng IH, Lien CC, Kao LS, Wang SJ, Fuh JL, Tzeng TT, Huang CY, Shiao YJ, Wong YH. Assessing the therapeutic potential of Graptopetalum paraguayense on Alzheimer’s disease using patient iPSC-derived neurons. Sci. Rep. 2019 Dec 17;9(1):19301. doi: 10.1038/s41598-019-55614-9. [PDF] [PubMed] [JCR] [WOS]
21. Hsu YT, Chang YG, Liu YC, Wang KY, Chen HM, Lee DJ, Yang SS, Tsai CH, Lien CC, Chern YJ. Enhanced Na+-K+-2Cl- cotransporter 1 underlies motor dysfunction in Huntington’s disease. Mov. Disord. 2019 Jun;34(6):845-857. (Co-corresponding author) [PDF] [PubMed] [cover] [JCR] [WOS]
22. Chen CY, Di Lucente J, Lin YC, Lien CC, Rogawski MA, Maezawa I, Jin LW. Defective GABAergic neurotransmission in the nucleus tractus solitarius in Mecp2-null mice, a model of Rett syndrome. Neurobiol. Dis. 2018 Jan; 109(Pt A): 25-32. [PDF] [PubMed] [JCR] [WOS]
23. Huang CY, Lien CC, Cheng CF, Yen TY, Chen CJ, Tsaur ML. K+ channel Kv3.4 is essential for axon growth by limiting the influx of Ca2+ into growth cones. J. Neurosci. 2017 April; 37(17): 4433-4449. [PDF] [PubMed] [JCR] [WOS]
24. Kuo YL, Cheng JK, Hou WH, Chang YC, Du PH, Jian JJ, Rau RH, Yang JH, Lien CC, Tsaur ML. K+ channel modulatory subunits KChIP and DPP participate in Kv4-mediated mechanical pain control. J. Neurosci. 2017 April; 37(16): 4391-4404. [PDF] [PubMed] [JCR] [WOS]
25. Lee CT, Kao MH, Hou WH, Wei YT, Chen CL, Lien CC. Causal evidence for the role of specific GABAergic interneuron types in entorhinal recruitment of dentate granule cells. Sci. Rep. 2016 Nov; 6: 36885. (Corresponding author) [PDF] [PubMed] [Supplementary Information] [JCR] [WOS]
26. Wu CC, Lien CC, Hou WH, Chiang PM, Tsai KJ. Gain of BDNF function in engrafted neural stem cells promotes the therapeutic potential for Alzheimer’s disease. Sci. Rep. 2016 Jun; 6: 27358. [PDF] [PubMed] [JCR] [WOS]
27. Hsu TT, Lee CT, Tai MH, Lien CC. Differential recruitment of dentate gyrus interneuron types by commissural versus perforant pathways. Cereb. Cortex. 2016 Jun; 26(6): 2715-2727. (Corresponding author) [PDF] [Supporting information] [PubMed] [JCR] [WOS]
28. Hou WH, Kuo N, Fang GW, Huang HS, Wu KP, Zimmer A, Cheng JK, Lien CC. Wiring specificity and synaptic diversity in the mouse lateral central amygdala. J. Neurosci. 2016 April; 36(16): 4549-4563. (Corresponding author) (Featured Article) [PDF] [PubMed] [JCR] [WOS]; also see Editor’s Commentary [PDF] [PDF (Chinese Ver.)]
29. Chang CP, Lee CT, Hou WH, Lin MS, Lai HL, Chien CL, Chang C, Cheng PL, Lien CC, Chern Y. Type VI adenylyl cyclase negatively regulates GluN2B-mediated LTD and spatial reversal learning. Sci. Rep. 2016 Mar; 6(22529): 1-16. (*co-corresponding author) [PDF] [Supporting information] [PubMed] [JCR] [WOS]
30. Chiang PH, Chien TC, Chen CC, Yanagawa Y, Lien CC. ASIC-dependent LTP at multiple glutamatergic synapses in amygdala network is required for fear memory. Sci. Rep. 2015 May; 5: 10143. (Corresponding author) [PDF] [Supporting information] [PubMed] [JCR] [WOS]
31. Lin SH, Chien YC, Chiang WW, Liu YZ, Lien CC, Chen CC. Genetic mapping of ASIC4 and contrasting phenotype to ASIC1a in modulating innate fear and anxiety. Eur. J. Neurosci. 2015 Jun; 41(12): 1553-1568. [PDF] [PubMed] [JCR] [WOS]
32. Chen WT, Hsieh YF, Huang YJ, Lin CC, Lin YT, Liu YC, Lien CC, Cheng IH. G206D mutation of Presenilin-1 reduces Pen2 interaction, increases Aβ42/Aβ40 ratio and elevates ER Ca2+ accumulation. Mol. Neurobiol. 2015 Dec; 52(3): 1835-1849. [PubMed] [JCR] [WOS]
33. Cheng CF, Cheng JK, Chen CY, Lien CC, Chu D, Wang SY, Tsaur ML. Mirror-image pain is mediated by NGF produced from tumor necrosis factor alpha-activated satellite glia after peripheral nerve injury. Pain. 2014 May; 155(5): 906-920. [PDF] [Supporting information] [PubMed] [JCR] [WOS]
34. Liu YC, Cheng JK, Lien CC. Rapid dynamic changes of dendritic inhibition in the dentate gyrus by presynaptic activity patterns. J. Neurosci. 2014 Jan 22; 34(4): 1344-1357. (Corresponding author) [PDF] [PubMed] [JCR] [WOS]
35. Chan CF, Kuo TW, Weng JY, Lin YC, Chen TY, Cheng JK, Lien CC. Ba2+– and bupivacaine-sensitive background K+ conductances mediate rapid EPSP attenuation in oligodendrocyte precursor cells. J. Physiol. 2013 Oct 1; 591(19): 4843-4858. (*: Co-First author; Corresponding author) [PDF] [PubMed] [JCR] [WOS]; also see the perspective by Battefeld and Kole in the same issue; also selected as the Editor Choice in the same issue [PDF]
36. Sun YY, Lin SH, Lin HC, Hung CC, Wang CY, Lin YC, Hung KS, Lien CC, Kuan CY, Lee YH. Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes. PLoS ONE. 2013 Jul 9; 8(7): e69019. [PDF] [Supporting information] [PubMed] [JCR] [WOS]
37. Wu PY, Huang YY, Chen CC, Hsu TT, Lin YC, Weng JY, Chien TC, Cheng IH, Lien CC. Acid-sensing ion channel-1a is not required for normal hippocampal LTP and spatial memory. J. Neurosci. 2013 Jan 30; 33(5): 1828-1832. (Corresponding author) [PDF] [PubMed] [JCR] [WOS]
38. Lee YC, Alexandra D, Majczenko K, Huang YH, Liu YC, Lien CC, Tsai PC, Ichikawa Y, Goto J, Monin ML, Li JZ, Chung MY, Mundwiller E, Shakkottai V, Liu TT, Tesson C, Lu YC, Brice A, Tsuji S, Burmeister M, Stevanin G, Soong BW. Mutations in KCND3 cause spinocerebellar ataxia type 22. Ann. Neurol. 2012 Dec; 72(6): 859-869. [PDF] [Supporting Information] [PubMed] [JCR] [WOS]
39. Majumder P, Chen YT, Bose JK, Wu CC, Cheng WC, Cheng SJ, Fang YH, Chen YL, Tsai KJ, Lien CC, Shen CK. TDP-43 regulates the mammalian spinogenesis through translational repression of Rac1. Acta. Neuropathol. 2012 Aug; 124(2): 231-245. Epub 2012 Jul 4. [PDF] [Supplementary Material] [PubMed] [JCR] [WOS]
40. Chiang PH, Wu PY, Kuo TW, Liu YC, Chan CF, Chien TC, Cheng JK, Huang YY, Chiu CD, Lien CC. GABA is depolarizing in hippocampal dentate granule cells of the adolescent and adult rats. J. Neurosci. 2012 Jan 4; 32(1): 62-67. (*: Co-First author; Corresponding author) [PDF] [PubMed] [JCR] [WOS]
41. Lin YC, Liu YC, Huang YY, Lien CC. High-density expression of Ca2+-permeable ASIC1a channels in NG2 glia of rat hippocampus. PLoS ONE. 2010 Sep 10; 5(9): e12665-e12672. (Corresponding author) [PDF] [PubMed] [JCR] [WOS]
42. Chu KC, Chiu CD, Hsu TT, Hsieh YM, Huang YY, Lien CC. Functional identification of an outwardly rectifying pH- and anesthetic-sensitive leak K+ conductance in hippocampal astrocytes. Eur. J. Neurosci. 2010 Sep; 32(5): 725-735. (Corresponding author) [PDF] [Supporting Information] [PubMed] [JCR] [WOS]
43. Weng JY, Lin YC, Lien CC. Cell type-specific expression of acid-sensing ion channels in hippocampal interneurons. J. Neurosci. 2010 May 12; 30(19): 6548-6558. (Corresponding author) [PDF] [Supplemental Data] [PubMed] [JCR] [WOS]
44. Chiang PH, Yeh WC, Lee CT, Weng JY, Huang YY, Lien CC. M1-Like muscarinic acetylcholine receptors regulate fast-spiking interneuron excitability in rat dentate gyrus. Neuroscience. 2010 Aug 11; 169(1): 39-51. Epub 2010 Apr 28. (Corresponding author) [PDF] [PubMed] [JCR] [WOS]
45. Liao CW, Lien CC. Estimating intracellular Ca2+ concentrations and buffering in a dendritic inhibitory hippocampal interneuron. Neuroscience. 2009 Dec 29; 164(4): 1701-1711. Epub. 2009 Sep 25. (Corresponding author) [PDF] [PubMed] [JCR] [WOS]
46. Aponte Y, Lien CC, Reisinger E, Jonas P. Hyperpolarization-activated cation channels in fast-spiking interneurons of rat hippocampus. J. Physiol. 2006 Jul 1; 574(Pt 1): 229-243. Epub 2006 May 11. [PDF] [PubMed] [JCR] [WOS]
47. Lien CC, Mu Y, Vargas-Caballero M, Poo MM. Visual stimuli-induced LTD of GABAergic synapses mediated by presynaptic NMDA receptors. Nat. Neurosci. 2006 Mar; 9(3): 372-380. Epub 2006 Feb 12. [PDF] [Supplementary Information] [PubMed] [JCR] [WOS]
48. Oliver D, Lien CC, Soom M, Baukrowitz T, Jonas P, Fakler B. Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids. Science (Research Article) 2004 Apr 9; 304(5668): 265-270. Epub 2004 Mar 18. (*equal contribution). [PDF] [Supporting Online Material] [PubMed] [JCR] [WOS]
49. Lien CC, Jonas P. Kv3 potassium conductance is necessary and kinetically optimized for high-frequency action potential generation in hippocampal interneurons. J. Neurosci. 2003 Mar 15; 23(6): 2058-2068. [PDF] [PubMed] [JCR] [WOS]
50. Lien CC, Martina M, Schultz J, Ehmke H, Jonas P. Gating, modulation, and subunit composition of voltage-gated K+ channels in dendritic inhibitory interneurones of rat hippocampus. J. Physiol. 2002 Jan 15; 538(Pt 2): 405-419. [PDF] [PubMed] [JCR] [WOS]

Published Book Chapter

- Martina M*, Lien CC* (2018). Book Chapter: Physiological properties of hippocampal neurons. Hippocampal Microcircuits: 91-126. (*corresponding) [PDF] [Link]
- 連正章。Potassium Channels for High-Frequency Action Potential Generation in GABAergic Interneurons of Rat Hippocampus. 2003年 PhD thesis. [PDF] or PDF from https://freidok.uni-freiburg.de/data/749

Research Interest

My lab is interested in understanding brain circuits and behavior in health and disease. More recently we have become increasingly interested in neural mechanisms underlying emotion and cognition. We mainly focus on two key regions in the limbic system, that is, the hippocampus and amygdala. To establish causal relationships between brain circuits and behavior, we combine the optogenetic or chemogenetic approach with different readout methodologies including electrophysiology and calcium imaging in freely moving animals. To uncover the input-output organization of the network, we employ optogenetics-assisted circuit mapping in brain slices maintained in vitro or in intact brains. Over the past decade, we have highlighted the relevance of GABAergic circuitry in both network and cognitive functions.

One of the grand challenges in brain research is to understand the wiring principle of the brain. Over the past decade, I mainly focused on three major topics:
First, what are the hierarchy, diversity and variability of central neurons?
Second, what is the cell type-specific expression pattern of channel/receptors in the brain and what is its physiological significance?
Third, how neurotransmission at central synapses is regulated and integrated along dendrites?
Mutidisciplinary approaches are currently used in my lab including: electrophysiology such as patch-clamp technique, fast calcium imaging, high-speed voltage imaging, two-photon imaging, single-cell RT-PCR, 3D morphological reconstruction, optogenetics, neuronal modeling, molecular biology, mouse genetics, animal behavioral study, etc.

Specializations and Course Offerings:

一、Neurophysiology – Course Overview [Link]
二、Neural Simulation – Course Introduction [Link]

Current members

Assistant & Postdoctoral fellow
Joan Tung, Administrative Staff	Yu-Chiuan Wang, Postdoctoral fellow	Ju-Yun Weng, Postdoctoral fellow	Yu-Jui Li, Research assistant	Bella Yang, Research assistant
PhD student
Jakobus Gerick Pantouw, PhD student	Ivan Liou, PhD student	Noah A. Omeiza, PhD student

Master student
Shameemun Naseer, MS student	Yu-Ling Chou, MS student	Yung-Chen Tsai, MS student
Undergraduate Student
Vy Thi Thanh Nguyen, Undergraduate student	Tri-Linh Thi Nguyen, Undergraduate student

Former members

Postdoctoral fellow
Ju-Yun Weng, PhD student (graduated) Postdoctoral fellow	Yu-Chao Liu, PhD student (graduated) Postdoctoral fellow	Wen-Hsien Hou, PhD student (graduated) Postdoctoral fellow
PhD student
Ju-Yun Weng, PhD student (graduated)	Yu-Chao Liu, PhD student (graduated)	Jhih-Wei Hsu, PhD student (dropout)	Ta-Chun Chien, PhD student (dropout)	Po-Han Chiang, PhD student (graduated)
Tsan-Ting Hsu, PhD student (graduated)	Cheng-Da Lee, PhD student (graduated)	Wen-Hsien Hou, PhD student (graduated)	Chien-Chun Chen, PhD student (dropout)	Kai-Yi Wang, PhD student (graduated)
Musa Iyiola Ajibola, PhD student (graduated)	Hung-Ling Chang Chien, PhD student (dropout)	Zhu-Sen Yang, PhD student (dropout)
Master student
Wei-Chun Yeh, MS student (graduated)	Kuo-Chang Chu, MS student (graduated)	Chen-Wei Liao, MS student (graduated)	Yen-Chu Lin, MS student (graduated)	Pu-Yeh Wu, MS student (graduated)
Tzu-Wei Kuo, MS student (graduated)	Chu-Fang Chan, MS student (graduated)	Ning Kuo, MS student (graduated)	Ting-Yu Chen, MS student (graduated)	Chieh-Ju Chen, MS student (graduated)
Ting-Yun Yen, MS student (graduated)	Min-Hua Kao, MS student (graduated)	Wai-Yi Wong, MS student (graduated)	Yu-Ting Wei, MS student (graduated)	Chia-Wei Yeh, MS student (graduated)
Li-Wen Chou, MS student (graduated)	Zhu-Sen Yang, MS student (graduated)	Ssu-Min Wang, MS student (dropout)

Collaborators

Domestic

Dr. Yi-Hsuan Lee

Department and Institute of Physiology, National Yang Ming Chiao Tung University

Dr. Irene Han-Juo Cheng

Institute of Brain Science, National Yang Ming Chiao Tung University

Dr. Jen-Kun Cheng

Department of Anesthesia, Mackay Memorial Hospital

Dr. Yu-Yin Huang

Department of Anesthesia, Cheng Hsin General Hospital

Dr. Yi-Juang Chern

Institute of Biomedical Sciences, Academia Sinica

Dr. Chen, Chih-Cheng

Institute of Biomedical Sciences, Academia Sinica

Dr. Hwai-Jong Cheng

Institute of Molecular Biology, Academia Sinica

Dr. Pei-Hsin Huang

Department of Pathology and Graduate Institute of Pathology, National Taiwan University

International

Dr. Imre Vida

Institute of Integrative Neuroanatomy, Charité – Universitätsmedizin Berlin

Dr. Gábor Tamás

University of Szeged, Department of Physiology

Dr. Hannah Monyer

Department of Clinical Neurobiology, University of Heidelberg

Dr. Francesco Ferraguti

Department of Pharmacology, Medical University of Innsbruck

Dr. Chou-Long Huang

Department of Internal Medicine, College of Medicine, University of Iowa Caver

Media Coverage

(Video) Lien Lab Introduction

(Video) Life in Lien Lab

Related Publications(For additional in-depth articles, please refer to the LIENLAB_Media Coverage section)

2025 陽交大團隊利用AI透視分析輕量化動作捕捉系統的臨床應用

In 2025, a research team from National Yang Ming Chiao Tung University leveraged AI-driven vision analysis to explore the clinical applications of lightweight motion capture systems, potentially revolutionizing fields such as rehabilitation and medical diagnostics.

2024 陽交大跨國團隊深掘小鼠恐懼記憶登國際期刊，有望治療PTSD

International Team at NYCU Publishes Breakthrough Study on Fear Memory in Mice, Opening New Avenues for PTSD Therapy

2023 台美研究破解滲透壓感測之謎揭神經機制控尿液濃淡

In 2023, a groundbreaking study by a Taiwan-U.S. research team solved the mystery of osmoreception, revealing the neural mechanisms that control urine concentration.

2022 台灣科技媒體中心記者會 (2022/11/14)

2022 Taiwan Science Media Center Press Conference

1. 慢性疼痛有解方？陽明交大攜手北榮最新研究登上國際期刊《自由時報》

2. 這種痛不是真的痛！　研究團隊揭慢性疼痛關鍵《壹蘋新聞網》

3. 登國際期刊：有望解決慢性疼痛、憂鬱焦慮！《yahoo新聞》

4. 全球30％的人受慢性疼痛影響陽明交大與北榮團隊解謎團《中時新聞網》

5.發現腦中「關鍵細胞」陽交大、北榮研究登國際期刊：有望解決慢性疼痛、憂鬱焦慮《民生頭條》

2021諾貝爾生醫獎記者會 (2021/10/04)

2021 Nobel Prize in Physiology or Medicine Press Conference

1. 辣椒的辣度與熱度如何形成諾貝爾生醫獎揭開人類的奧秘《SMC 台灣科技媒體中心》

2. 研究神經受體獲諾貝爾醫學獎 2得主與台灣有淵源《中央社》

3. 諾貝爾醫學獎2得主都與台灣有淵源他娶台裔妻子曾來台演講《中時新聞網》

4. 諾貝爾醫學獎解開人類感知溫度及壓力之謎！2位美國科學家共獲殊榮其中一位是台灣女婿《中時新聞網》

5. 研究「感知」獲諾貝爾醫學獎兩得主與台灣早結緣《中時新聞網》

2021科技部記者會 (2021/09/27)

2021 Ministry of Science and Technology Press Conference

1. NYCU researcher leads team in anxiety findings REGULATING ANXIETY: Chen Hong-chen, director-general of the Department of Life Sciences, said about 2.8 million people in 2019 sought anxiety treatment《The Taipei Times》

2. Unveiling anxiety-related brain circuits in the hippocampus—Taiwan research team found a link between single neuron activity and anxiety-related behavior, published as a cover story in Cell Reports《MOST》

3. 揭開焦慮神經迴路的神秘面紗—台歐美跨國合作成果登上Cell Reports封面故事《科技部》

4. 揭開焦慮神經迴路的神秘面紗，台歐美跨國合作成果登上 Cell Reports 封面故事《國立陽明交通大學新聞網》

5. 本院連正章院長研究團隊揭開焦慮神經迴路的神秘面紗，台歐美跨國合作成果登上 Cell Reports 封面故事《國立陽明交通大學生命科學院》

其他

Other Reports

Contact Us

E-mail: cclien@ym.edu.tw or cclien@nycu.edu.tw

Office phone: +886-2-2826-7325

Lab phone: +886-2-2826-7000 ext. 66090

Fax: +886-2-2821-5307

Mailing address: No.155, Sec. 2, Linong St., Beitou Dist., Taipei city 112, Taiwan.
Institute of Neuroscience, National Yang Ming Chiao Tung University

Directions: Room 750, Library, Information and Research Building