David Niddam 尼大衛 - 國立陽明交通大學神經科學研究所

David Niddam Assistant Professor

E-mail: niddam@nycu.edu.tw
TEL: +886-2-2826-7389
David Niddam_CV

EXPERIENCE PUBLICATIONS LABORATORY

Educations

1998-2002 Biomedical Science and Engineering
Ph.D. in University of Aalborg, Denmark

1996-1998 University of Copenhagen, Denmark
M.Sc. in Physics/ Biophysics

1992-1996 University of Copenhagen, Denmark
B.Sc. in Physics/ Biophysics

Positions

2020-迄今國立陽明交通大學腦科學中心　研究員

2013-迄今國立陽明交通大學腦科所　兼任副教授

2008-2020 國立陽明大學腦科學中心　副研究員

2004-迄今台北榮民總醫院　教學研究部　整合性腦功能研究小組　副研究員

2003-2008 國立陽明大學腦科學中心　助理研究員

2002-2003 國立陽明大學神經科學研究中心　博士後研究員

Honors

2017 Second place of the best articles of the year, Veterans General Hospitals and University System of Taiwan Joint Research Program, (第12屆榮台聯大研究優秀論文獎第三名) “Niddam DM, Lai KL, Fuh JL, Chuang CY, Chen WT, Wang SJ. Reduced functional connectivity between salience and visual networks in migraine with aura. Cephalalgia 2016 Jan;36(1):53-66.”

Representative Papers

- Niddam DM*, Wang SJ, Tsai SY*. Pain sensitivity and the primary sensorimotor cortices: a multimodal neuroimaging study. PAIN 2021 Mar 1;162(3):846-855
- Lai KL, Niddam DM*. Brain metabolism and structure in chronic migraine. Curr Pain Headache Rep. 2020 Nov:24(11):69
- Niddam DM*, Wang SJ. Reply to Letter to the Editor, “Creatine loading for chronic migraine”. Cephalalgia 2020 Jul;40(8):880-881
- Lai KL, Niddam DM, Fuh JL, Chen WT, Wu JC, Wang SJ. Reply to Letter to the Editor: Insights into chronic migraine pathophysiology-what measure of gray matter reveal. Cephalalgia 2020 Sep;40(10):1138-1139
- Lai KL, Niddam DM, Fuh JL, Chen WT, Wu JC, Wang SJ. Cortical morphological changes in chronic migraine in a Taiwanese cohort: Surface- and voxel-based analyses. Cephalalgia 2020 May;40(6):575-585.
- Niddam DM, Lai KL, Tsai SY, Lin YR, Chen WT, Fuh JL, Wang SJ*. Brain metabolites in chronic migraine patients with medication overuse headache. Cephalalgia 2020 Jul;40(8):851-862
- Niddam DM*, Lee SH, Su YT, Chan RC. Altered cortical morphology in patients with chronic shoulder pain. Neurosci Lett 2019 Nov 1; 712:134515.
- Niddam DM*, Lai KL, Tsai SY, Lin YR, Chen WT, Fuh JL, Wang SJ*. Neurochemical changes in the medial wall of the brain in chronic migraine. Brain 2018 Feb 1;141(2):377-390.
- Cheng CH*, Tsai SY, Liu CY, Niddam DM*. Automatic inhibitory function in the human somatosensory and motor cortices: An MEG-MRS study. Sci Rep 2017 Jun 26;7(1):4234.
- Cheng CH, Niddam DM, Hsu SC, Liu CY, Tsai SY. Resting GABA concentration predicts inhibitory control during an auditory Go-Nogo task. Exp Brain Res 2017 Oct 9
- Niddam DM*, Lee SH, Su YT, Chan RC. Brain structural changes in patients with chronic myofascial pain. Eur J Pain 2017 Jan;21(1):148-158.
- Lai KL, Niddam DM, Fuh JL, Chen SP, Wang YF, Chen WT, Wu JC, Wang SJ. Flunarizine versus topiramate for chronic migraine prophylaxis: a randomized trial. Acta Neurol Scand. 2017 Apr;135(4):476-483.
- Niddam DM, Lai KL, Fuh JL, Chuang CY, Chen WT, Wang SJ. Reduced functional connectivity between salience and visual networks in migraine with aura. Cephalalgia 2016 Jan;36(1):53-66.

Research Interest

The primary focus of my research is on understanding how the brain contributes to the development and maintenance of chronic pain, in particular in patients with chronic migraine and chronic myofascial pain. To advance this research, I apply state-of-the-art MRI-based techniques to measure alterations in brain function, metabolism and structure. Novel techniques are developed and implemented both with respect to MRI sequences and data analysis approaches. Recent research is focused on three inter-linked topics: (1) brainstem functional imaging and its application to migraine patients; (2) investigation of the role of the reward system in chronic migraine patients with medication overuse headache (MOH); (3) brain changes across the different migraine phases. In the first line of research, brainstem imaging will be applied in patients with episodic and chronic migraine. In the second line of research, the brain mechanisms underlying MOH in chronic migraine patients is explored with task-based functional magnetic resonance imaging. The intertemporal choice task (ITC) is used to probe the reward system or more specifically the processing of the subjective temporal discount factor. In addition, transcranial direct current stimulation of the dorsolateral prefrontal cortex is applied to explore whether the subjective discount factor can be modulated. In the third line of research, cross-sectional data from episodic migraine patients in inter-ictal, pre-ictal, ictal, and post-ictal phases are analyzed using structural MRI measures, such as voxel- and surface-based morphometry, as well as resting-state functional connectivity measures. All research is performed in close collaboration with clinicians and MR physicists.

Research Grant Support in the past 5 years (2016-2021)

Ministry of Science and Technology, MOST 110-2314-B-A49A-536, David M. Niddam (PI) 2021/08/01 – 2022/07/31 Task-related and resting-state brainstem networks in chronic migraine patients with medication overuse headache
Ministry of Science and Technology, MOST 107-2314-B-010 -018 -MY3, David M. Niddam (PI) 2018/08/01 – 2021/07/31 Neural mechanisms of reward-based decision making in chronic migraine with medication overuse headache
Ministry of Science and Technology, MOST 105-2628-B-010 -011 -MY2, David M. Niddam (PI) 2016/08/01 – 2018/07/31 Predicting the response to preventive medication in patients with chronic migraine using magnetic resonance spectroscopy
Ministry of Science and Technology, MOST 102-2628-B-010-004-MY3, David M. Niddam (PI) 2013/08/01 – 2016/07/31 Neuroimaging and neuromodulation of pain in refractory tension type headache
Ministry of Science and Technology, MOST 111-2321-B-A49-004, Role: Co-PI Decoding pain sensitivity in migraine with multimodal brainstem imaging markers/ 以多模組腦幹神經標誌解碼偏頭痛的痛覺敏感性－以多模組腦幹神經標誌解碼偏頭痛的痛覺敏感性(2/2)
Ministry of Science and Technology, MOST 110-2321-B-010 -005, Role: Co-PI Decoding pain sensitivity in migraine with multimodal brainstem imaging markers/ 以多模組腦幹神經標誌解碼偏頭痛的痛覺敏感性-以多模組腦幹神經標誌解碼偏頭痛的痛覺敏感性(1/2) 2021/01/01- 2021/12/31
Ministry of Science and Technology, MOST 109-2314-B-075 -049 -, Role: Co-PI 慢性偏頭痛患者之預防性治療：臨床與多模神經影像學之相關性 2020/08/01 – 2021/07/31
Ministry of Science and Technology, MOST 105-2321-B-010-002-, Role: Co-PI 2016/08/01 – 2017/07/31 穿顱直流電刺激於嚴重難治型原發性痛經之療效：臨床及基因神經造影研究(3/3)